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Smartshoes for Freezing of Gait in Parkinson’s Disease

This pilot study evaluates the safety, tolerability, and potential benefit of NUSHU provides vibration feedback for reducing freezing of gait in Parkinson’s disease.

The study is conducted at Stanford University, Palo Alto, California, United States, 94305.

Eligibility Criteria

Inclusion criteria:
For patients with Parkinson disease:

diagnosis of PD according to the UK Brain Bank criteria
Hoehn and Yahr stages 2 to 3 during the ON phase of PD medication
Self-report episodes of FoG based on item 1 of the NFOG-Q, and score of 3 on item 2, part II

For patients with Parkinson disease withOUT freezing of gait:

diagnosis of PD according to the UK Brain Bank criteria
Hoehn and Yahr stages 2 to 3 during the ON phase of PD medication

For all participants (PD with or without freezing, or age-matched controls):

adult age 40-80
able to walk 10 minutes at baseline
able to provide consent
able to read and write in English at an 8th grade level.

Exclusion criteria:
For all participants (PD with or without freezing, or age-matched controls):

moderate to severe peripheral neuropathy (based on self report or clinical exam using vibration tuning fork) which may limit ability to sense the vibratory feedback
use of orthotics incompatible with the haptic wearable shoes
severe balance deficits or daily falls at baseline
patients with dementia (MoCA<18) who are not able to appropriately provide consent for the study
pregnant persons